GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs7849270 | 1 | rs6478867 | chr9:131903923 | CRAT | chr9:131857075-131873070:- | -0.43 | -5.07 | 1.99E-6 | Blood metabolite ratios |
| THYM | cis | rs4237643 | 1 | rs6485438 | chr11:43686618 | HSD17B12 | chr11:43702143-43878160:+ | -0.6 | -6.8 | 9.28E-10 | Forced vital capacity |
| THYM | cis | rs4237643 | 1 | rs6485443 | chr11:43696316 | HSD17B12 | chr11:43702143-43878160:+ | 0.65 | 7.65 | 1.61E-11 | Forced vital capacity |
| THYM | cis | rs2028299 | 1 | rs6496609 | chr15:90379632 | AP3S2 | chr15:90373832-90456222:- | -0.43 | -4.89 | 4.09E-6 | Type 2 diabetes |
| THYM | cis | rs8078723 | 1 | rs6503530 | chr17:38161823 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.52 | 1.73E-15 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs7223966 | 1 | rs6504167 | chr17:61693194 | TCAM1P | chr17:61934376-61941738:+ | -0.52 | -4.3 | 4.14E-5 | Body mass index |
| THYM | cis | rs7223966 | 1 | rs6504169 | chr17:61709145 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.33 | 3.63E-5 | Body mass index |
| THYM | cis | rs7223966 | 1 | rs6504170 | chr17:61709168 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.4 | 2.78E-5 | Body mass index |
| THYM | cis | rs7223966 | 1 | rs6504171 | chr17:61710010 | TCAM1P | chr17:61934376-61941738:+ | -0.53 | -4.38 | 3.02E-5 | Body mass index |
| THYM | cis | rs7223966 | 1 | rs6504173 | chr17:61735056 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.47 | 2.2E-5 | Body mass index |
| THYM | cis | rs9902453 | 1 | rs6505152 | chr17:28331466 | EFCAB5 | chr17:28256874-28435469:+ | -0.31 | -4.25 | 5.04E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs10416265 | 1 | rs6510348 | chr19:33601946 | GPATCH1 | chr19:33571786-33621318:+ | 0.37 | 4.33 | 3.69E-5 | Bone properties (heel) |
| THYM | cis | rs911119 | 1 | rs6515375 | chr20:23610841 | CST9 | chr20:23583049-23586610:- | -0.46 | -4.25 | 4.97E-5 | Chronic kidney disease |
| THYM | cis | rs1930961 | 1 | rs6519611 | chr22:25845855 | CRYBB2 | chr22:25615612-25627836:+ | 1.09 | 7.15 | 1.78E-10 | Bipolar disorder with mood-incongruent psychosis |
| THYM | cis | rs2273 | 1 | rs6532078 | chr4:76920809 | NAAA | chr4:76831809-76862166:- | -0.45 | -4.79 | 6.23E-6 | Longevity |